Abbysine PF is an exopolysaccharide from an extremophile organism living in deep-sea hydrothermal vents. It reduces the expression of I-CAM-1 to reduce irritation in sensitive skin, increase resistance to stressors, reduce reactivity and intolerance, and activate skin repair and restructuring processes.

Aldavine consists of two sulphated polysaccharides extracted from algae. It is a VEGF and PGE2 inhibitor and MMP-2 inhibitor that also inhibits angiogenesis, helping to calm vascular reactivity and reduce visible redness.

How do I use Circadia Chrono-Calm Calming Serum?

After cleansing, apply several drops to the face and neck morning and night. Pat into the skin and follow with a moisturizer to maximize soothing and redness-reducing benefits.

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Circadia Chrono-Calm Serum

Name: Circadia Chrono-Calm Calming Serum
Brand: Circadia
Availability: InStock

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Circadia Chrono-Calm Serum

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Circadia · Calming Serum · AM & PM · Retail & Pro Sizes

Chrono-Calm Calming Serum

Telangyn + MAXnolia + Abbysine PF + Aldavine — multi-pathway calming for chronically red, sensitive, and reactive skin.

A lightweight, water-based serum that calms and soothes irritation while restoring balance and resilience to sensitive, reactive skin. 0.5 oz / 15 mL retail.

Telangyn PeptideMAXnoliaAbbysine PFAldavineQuenchT0.5 oz / 15 mL

7Calming Actives

AM/PMTwice Daily

WaterBased Formula

Pro+ Retail Sizes

Calming & Redness-Reducing Serum

Multi-Pathway Calming for Chronically
Red and Reactive Skin.

Chrono-Calm Calming Serum is Circadia's targeted solution for skin that suffers from chronic redness, inflammation, visible capillaries, and the irritations associated with sensitivity and rosacea. Unlike single-ingredient calming serums, Chrono-Calm addresses redness through multiple biological pathways simultaneously. Telangyn (Acetyl Tripeptide-33) works at the interleukin signaling level, decreasing the release of inflammatory messengers to reduce redness, dilated blood vessels, tissue degradation, and post-inflammatory hyperpigmentation. MAXnolia (Magnolia bark and grape seed extract blend) protects against chronic inflammation, neutralizes internal aging factors, and reduces skin redness. Abbysine PF is an exopolysaccharide from a deep-sea extremophile that reduces I-CAM-1 expression to decrease irritation, increase stress resistance, reduce reactivity, and activate skin repair. Aldavine (sulphated polysaccharides from algae) inhibits VEGF, PGE2, and MMP-2 while also inhibiting angiogenesis — directly targeting vascular reactivity. QuenchT reduces stinging, tingling, and burning sensations and counters free radical damage. Ginger Extract provides anti-inflammatory, analgesic, and antioxidant support. Marshmallow Extract is anti-inflammatory and film-forming to protect against irritating agents.

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Telangyn

Peptide — reduces interleukins, redness & dilated vessels

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MAXnolia

Magnolia + grape seed — neutralizes inflammation

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Abbysine PF

Deep-sea exopolysaccharide — activates skin repair

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Aldavine

Algae polysaccharides — VEGF & PGE2 inhibitor

Key Actives

The Science Behind the Calm

Calming Peptide

Telangyn

Acetyl Tripeptide-33 — decreases facial redness and skin disorders causing the release of interleukins. Reduces redness, dilated blood vessels, tissue degradation, and post-inflammatory hyperpigmentation.

Anti-Inflammatory Blend

MAXnolia

Extract blend of Magnolia bark (Magnolia Officinalis) and grape seeds (Vitis Vinifera). Protects skin against chronic inflammation, neutralizes internal aging factors, and reduces skin redness.

Deep-Sea Repair

Abbysine PF

Exopolysaccharide from an extremophile in deep-sea hydrothermal vents. Reduces I-CAM-1 expression to decrease irritation, increase resistance to stressors, reduce reactivity and intolerance, and activate skin repair processes.

Vascular Inhibitor

Aldavine

Two sulphated polysaccharides extracted from algae (Ascophyllum Nodosum + Asparagopsis Armata). VEGF and PGE2 inhibitor, MMP-2 inhibitor, and angiogenesis inhibitor — directly targets vascular reactivity and redness.

Sensation Reducer

QuenchT

Reduces stinging, tingling, and burning sensations. Reduces redness caused by sun exposure and counters the effects of free radicals — providing immediate comfort alongside longer-term calming benefits.

Botanical Duo

Ginger & Marshmallow

Ginger (Zingiber Officinale) — anti-inflammatory, analgesic, antipyretic, antioxidant, and antibacterial. Marshmallow (Althaea Officinalis) — anti-inflammatory and film-forming to protect against irritating agents.

Benefits

What It Does

Redness

Telangyn and Aldavine reduce facial redness, dilated vessels, and post-inflammatory hyperpigmentation through multiple pathways.

Calming

QuenchT, Ginger, and Marshmallow reduce stinging, burning, and irritation sensations for immediate and lasting comfort.

Resilience

Abbysine PF activates skin repair and restructuring to increase stress resistance and reduce long-term reactivity.

Directions

How to Apply

Morning and night. Follow with a moisturizer to maximize soothing benefits.

1

Cleanse

Cleanse skin thoroughly morning and evening. Gentle, pH-balanced cleansers are recommended for reactive skin types.

2

Apply Serum

Apply several drops to the face and neck. Pat gently into the skin — do not rub, as this can increase redness in reactive skin. Avoid contact with eyes.

3

Follow with Moisturizer

Follow with a moisturizer to seal in the serum and maximize soothing and redness-reducing benefits. In the morning, always finish with SPF.

Formulation

Ingredients

Key Actives

Telangyn (Acetyl Tripeptide-33) — decreases release of interleukins; reduces redness, dilated vessels, tissue degradation, and post-inflammatory hyperpigmentation.
MAXnolia (Magnolia Officinalis Bark Extract + Vitis Vinifera Seed Extract) — protects against chronic inflammation; neutralizes aging factors; reduces redness.
Abbysine PF (Alteromonas Ferment Extract) — deep-sea exopolysaccharide; reduces I-CAM-1; increases stress resistance; activates repair and restructuring.
Aldavine (Ascophyllum Nodosum + Asparagopsis Armata Extract) — sulphated polysaccharides; VEGF and PGE2 inhibitor; MMP-2 inhibitor; inhibits angiogenesis.
QuenchT — reduces stinging, tingling, and burning; reduces redness from sun exposure; counters free radicals.
Ginger Extract (Zingiber Officinale) — anti-inflammatory, analgesic, antipyretic, antioxidant, antibacterial.
Marshmallow Extract (Althaea Officinalis Root) — anti-inflammatory; film-forming; protects against irritating agents.
Panthenol (Provitamin B5) — regenerative and soothing.
Sodium Hyaluronate — deep hydration and plumping.

Full Ingredient List

Aqua/Water, Panthenol, Sodium Hyaluronate, Sorbitol, Glycerin, Butylene Glycol, Pentylene Glycol, Ascophyllum Nodosum Extract, Paullinia Cupana Fruit Extract, Ilex Paraguariensis Leaf Extract, Althaea Officinalis Root Extract, Avena Sativa Kernel Extract, Zingiber Officinale Root Extract, Alteromonas Ferment Extract, Potassium Sorbate, Cola Nitida Seed Extract, Sodium Metabisulfite, Beta-Glucan, Asparagopsis Armata Extract, Sodium Benzoate, Magnolia Officinalis Bark Extract, Tocopherol, Acetyl Tetrapeptide-40, Vitis Vinifera Seed Extract, Citric Acid, Caprylyl Glycol, Maltodextrin, Phenoxyethanol, Tetrasodium Glutamate Diacetate, Lecithin, Hexylene Glycol.

Specifications

Product Details

Brand	Circadia by Dr. Pugliese
Size	0.5 oz / 15 mL retail · Professional size available
Product Type	Lightweight water-based calming serum
Use	Morning and night after cleansing; follow with moisturizer
Skin Types	Red · Sensitive · Irritated/Compromised · Post-inflammatory · Rosacea-Prone
Key Technology	Telangyn · MAXnolia · Abbysine PF · Aldavine · QuenchT

FAQ

Common Questions

Everything you need to know about Chrono-Calm Calming Serum.

What is Circadia Chrono-Calm Calming Serum?

A lightweight, ultra-hydrating water-based serum that soothes chronically irritated skin and reduces the appearance of redness and dilated capillaries. Formulated with Telangyn, MAXnolia, Abbysine PF, Aldavine, and QuenchT for multi-pathway calming.

What is Telangyn?

Telangyn (Acetyl Tripeptide-33) is a peptide that decreases facial redness and skin disorders causing the release of interleukins. It reduces redness, dilated blood vessels, tissue degradation, and post-inflammatory hyperpigmentation at the cellular signaling level.

What is MAXnolia?

MAXnolia is a blend of Magnolia bark extract and grape seed extract that protects skin against chronic inflammation, neutralizes internal aging factors, and reduces skin redness.

What is Abbysine PF?

An exopolysaccharide from a deep-sea extremophile that reduces I-CAM-1 expression to decrease irritation in sensitive skin, increase resistance to stressors, reduce reactivity and intolerance, and activate skin repair and restructuring processes.

Is Chrono-Calm suitable for rosacea?

Yes — Telangyn, Aldavine, and MAXnolia specifically target the vascular and inflammatory mechanisms underlying rosacea-associated redness. The formula is also recommended for inflammatory acne-prone skin.

How do I use Chrono-Calm Calming Serum?

After cleansing, apply several drops to the face and neck morning and night. Pat gently into the skin and follow with a moisturizer to maximize soothing and redness-reducing benefits.

Ideal For

Who Is This For?

RednessSensitive SkinRosacea-ProneDilated CapillariesIrritated SkinPost-InflammatoryReactive SkinInflammatory Acne

For external use only. Apply to face and neck and avoid contact with eyes. If irritation occurs, discontinue use. Keep out of reach of children. Circadia products are developed for professional skincare use. Sold exclusively through authorized Circadia retailers. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer.

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Shipping & Returns

We ship within the US only.

1. Economy Shipping costs $11.99 and takes 5–8 business days.

2. Express Shipping costs $24.99 and takes 2–3 business days.

Yes, we accept returns within 30 days. Terms and conditions apply, see them here.

We accept a variety of payment methods including major credit cards (Visa, Mastercard, etc.), plus alternative payment options like Apple Pay, Shop Pay, and PayPal.

Once your order is placed and shipped, you will receive a confirmation email. Use the tracking information provided to follow delivery.

If you're missing tracking or have any concerns, please reach out to our customer support.

Products & Quality

Auréa Beauty is a proudly woman-owned online store offering premium, medical-grade skincare and advanced beauty devices.

All products are guaranteed authentic, dermatologist-recommended, sourced directly from trusted brands like Bio-Therapeutic, Circadia, GlyMed Plus, and TiZO.