What is glycation and how does it age the skin?

Glycation is a chemical process in which sugar molecules bind to proteins — including collagen and elastin — forming Advanced Glycation End-products (A.G.E.s). A.G.E.s cause collagen and elastin fibers to cross-link and stiffen, leading to loss of skin firmness, elasticity, and the formation of deep wrinkles such as smile lines. Glycation accelerates with age, high sugar intake, and UV exposure.

What is L-Carnosine and how does it prevent glycation?

L-Carnosine (a naturally occurring dipeptide of beta-alanine and histidine) has demonstrated anti-glycation and transglycation activity — meaning it both prevents glycation from occurring and can help reverse already-formed glycation cross-links. This preserves the structural integrity of collagen and elastin.

dGlyage (Tripeptide-9 Citrulline) reduces DNA damage resulting from Fenton reaction products and reduces metal-mediated A.G.E. formation — addressing the heavy-metal-catalyzed glycation pathway that is a secondary but significant driver of skin aging.

What is DermalRx LuShield?

DermalRx LuShield (Osmanthus Fragrans Flower Extract) detoxifies the skin from glycating agents and oxidants, protects biomolecules from the effects of glycation-induced inflammation, and prevents cell loss from A.G.E.s and elevated sugar levels.

How do I use Circadia Counter A.G.E. Balancing Serum?

Apply several drops to clean skin morning and evening. Gently massage into the face and neck until fully absorbed. Follow with moisturizer and SPF during the day. For optimal results, pair with Circadia Glyco-Guard both morning and night.

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Circadia Counter A.G.E. Balancing Serum

Name: Circadia Counter A.G.E. Balancing Serum
Brand: Circadia
Availability: InStock

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Circadia Counter A.G.E. Balancing Serum

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Circadia · Anti-Glycation Serum · Authorized Retailer · 0.5 oz

Counter A.G.E.
Balancing Serum

L-Carnosine + DermalRx LuShield + dGlyage + Derm SRC PF — fights glycation to preserve collagen, elastin, and firmness.

A powerful multi-pathway anti-glycation serum that combats the sugar-driven breakdown of collagen and elastin — preserving skin firmness, elasticity, and radiance while visibly reducing glycation-related aging signs like smile-line wrinkles. 0.5 oz / 15 mL.

L-Carnosine DermalRx LuShield dGlyage Derm SRC PF Edelweiss-ECO 0.5 oz / 15 mL

AM/PMDaily Use

A.G.E.Glycation Defense

AllSkin Types

PairWith Glyco-Guard

Multi-Pathway Anti-Glycation Serum

Prevents the Sugar-Driven Breakdown of Collagen
and Elastin for Lasting Firmness and Smoothness.

Circadia Counter A.G.E. Balancing Serum is a professional-grade treatment targeting glycation — one of the most significant and underaddressed drivers of skin aging. Glycation occurs when sugar molecules attach to collagen and elastin proteins, forming Advanced Glycation End-products (A.G.E.s) that cause structural cross-linking, stiffening, and degradation — leading to loss of firmness, elasticity, and the formation of deep expression wrinkles like smile lines. L-Carnosine (Carnosine + Decarboxy Carnosine HCL) is a naturally occurring dipeptide with demonstrated anti-glycation and transglycation activity — both preventing new glycation and helping reverse already-formed cross-links that have damaged collagen and elastin. DermalRx LuShield (Osmanthus Fragrans Flower Extract) detoxifies the skin from glycating agents and oxidants, protects biomolecules from glycation-induced inflammation, and prevents cell loss from A.G.E.s and elevated sugar levels. dGlyage (Tripeptide-9 Citrulline) reduces DNA damage from Fenton reaction products and inhibits metal-mediated A.G.E. formation — addressing a secondary but significant glycation pathway. Derm SRC PF (Bambusa Vulgaris + Pisum Sativum + Glucosamine HCL) is a triple complex of Bamboo Silica, Pea Extract, and Glucosamine that actively increases collagen, elastin, and hyaluronic acid synthesis — rebuilding the structural proteins glycation has degraded. Edelweiss-ECO (Leontopodium Alpinum) is rich in leontopodic acids A and B and chlorogenic acid, providing excellent antioxidant activity. Alpaflor Plantago AO (Plantago Lanceolata) enhances collagen production, supports wound healing, and provides anti-inflammatory support. For optimal results, pair with Circadia Glyco-Guard morning and night.

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L-Carnosine

Anti-glycation + transglycation — collagen defense

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DermalRx LuShield

A.G.E. detox — prevents glycation cell loss

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Derm SRC PF

Bamboo + Pea + Glucosamine — rebuilds matrix

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Authorized Retailer

100% authentic Circadia — guaranteed

Key Actives

Six Pathways Against Glycation-Driven Aging

Anti-Glycation Dipeptide

L-Carnosine

Carnosine + Decarboxy Carnosine HCL — a naturally occurring dipeptide with anti-glycation and transglycation activity. Prevents new glycation cross-links from forming and helps reverse existing ones — directly preserving collagen and elastin structural integrity.

Glycation Detox

DermalRx LuShield

Osmanthus Fragrans Flower Extract — detoxifies skin from glycating agents and oxidants, protects biomolecules from glycation-induced inflammation, and prevents cell loss from A.G.E.s and elevated sugar levels in the skin.

Metal-Mediated A.G.E. Inhibitor

dGlyage (Tripeptide-9 Citrulline)

Reduces DNA damage from Fenton reaction products (metal-catalyzed free radicals) and inhibits metal-mediated A.G.E. formation — addressing a distinct and significant secondary glycation pathway that accelerates structural collagen and elastin degradation.

Matrix Rebuilder

Derm SRC PF

A triple complex of Bamboo Silica (Bambusa Vulgaris), Pea Extract (Pisum Sativum), and Glucosamine HCL — increases the synthesis of collagen, elastin, and hyaluronic acid. Actively rebuilds the structural proteins that glycation has degraded.

Antioxidant Botanical

Edelweiss-ECO

Leontopodium Alpinum Flower/Leaf Extract — high in leontopodic acids A and B and chlorogenic acid, both of which have excellent antioxidant activity. Protects skin against oxidative stress and provides anti-collagenase support.

Collagen-Enhancing Botanical

Alpaflor Plantago AO

Plantago Lanceolata Leaf Extract — enhances collagen production, supports wound healing and anti-inflammatory activity. Contains Aucubin, flavonoids, phenylethanoids, tannins, and polysaccharides for comprehensive structural and soothing support.

Benefits

What It Does

Collagen & Elastin

L-Carnosine and dGlyage prevent new A.G.E. formation and help reverse existing glycation cross-links — preserving the structural proteins responsible for firmness and elasticity.

Firmness & Radiance

Derm SRC PF actively increases collagen, elastin, and HA synthesis while Edelweiss-ECO and Plantago AO provide antioxidant and collagen-enhancing support — improving firmness and luminosity over time.

Smile-Line Wrinkles

Glycation-related wrinkles — particularly expression lines like smile lines that deepen as collagen stiffens and cross-links — are specifically targeted by this formula's anti-glycation complex.

Directions

How to Use

Morning and evening on clean skin. Pair with Circadia Glyco-Guard for optimal anti-glycation results.

1

Cleanse

Cleanse thoroughly morning and evening. Counter A.G.E. Serum is applied to clean skin — before moisturizer, in serum layering order.

2

Apply Serum

Apply several drops to fingertips and gently massage into the face and neck until fully absorbed. Allow 60 seconds before applying the next product.

3

Follow With Moisturizer + Glyco-Guard

Follow with moisturizer and SPF in the morning. For optimal anti-glycation results, pair with Circadia Glyco-Guard both morning and night — the two products work synergistically to address glycation from multiple pathways simultaneously.

Formulation

Ingredients

Key Actives

L-Carnosine (Carnosine + Decarboxy Carnosine HCL) — anti-glycation and transglycation; preserves collagen and elastin by preventing and reversing A.G.E. cross-links.

DermalRx LuShield (Osmanthus Fragrans Flower Extract) — glycating agent detox; A.G.E. defense; protects biomolecules from glycation-induced inflammation; prevents A.G.E.-related cell loss.

dGlyage (Tripeptide-9 Citrulline) — reduces Fenton reaction DNA damage; inhibits metal-mediated A.G.E. formation.

Derm SRC PF (Bambusa Vulgaris Leaf/Stem Extract + Pisum Sativum Extract + Glucosamine HCL) — increases collagen, elastin, and hyaluronic acid synthesis; rebuilds degraded matrix.

Edelweiss-ECO (Leontopodium Alpinum Flower/Leaf Extract) — rich in leontopodic acids A and B; excellent antioxidant and anti-collagenase activity.

Alpaflor Plantago AO (Plantago Lanceolata Leaf Extract) — enhances collagen production; wound healing; anti-inflammatory; Aucubin, flavonoids, polysaccharides.

Sodium Hyaluronate — deep hydration; locks in moisture; supports elasticity.

Panthenol (Provitamin B5) — regenerative; soothing.

Full Ingredient List

Aqua/Water, Citric Acid, Glycerin, Panthenol, Pentylene Glycol, Sodium Hyaluronate, Propanediol, Glucosamine HCL, Osmanthus Fragrans Flower Extract, Lysine HCL, Lecithin, Pisum Sativum Extract, Bambusa Vulgaris Leaf/Stem Extract, Carnosine, Leontopodium Alpinum Flower/Leaf Extract, Sodium Metabisulfite, Decarboxy Carnosine HCL, Butylene Glycol, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate, Tripeptide-9 Citrulline, Tetrasodium EDTA, Phenoxyethanol, Caprylyl Glycol, Hexylene Glycol.

Specifications

Product Details

Brand	Circadia by Dr. Pugliese
Size	0.5 oz / 15 mL retail
Product Type	Anti-glycation balancing serum
Skin Types	All Skin Types · Aging / Premature Aging · Loss of Firmness
Application	Morning and evening on clean skin; apply several drops; massage into face and neck; follow with moisturizer and SPF (AM); pair with Glyco-Guard AM & PM for optimal results
Key Actives	L-Carnosine (Carnosine + Decarboxy Carnosine HCL), DermalRx LuShield (Osmanthus Fragrans), dGlyage (Tripeptide-9 Citrulline), Derm SRC PF (Bambusa Vulgaris + Pisum Sativum + Glucosamine HCL), Edelweiss-ECO (Leontopodium Alpinum), Alpaflor Plantago AO, Sodium Hyaluronate, Panthenol
Pairs With	Circadia Glyco-Guard — for optimal anti-glycation results, use both products AM & PM
Sold By	Auréa Beauty — Authorized Circadia Retailer (myaurea.beauty)

FAQ

Common Questions

Everything you need to know about Circadia Counter A.G.E. Balancing Serum.

What is Circadia Counter A.G.E. Balancing Serum?

A powerful anti-glycation serum that preserves collagen and elastin from sugar-driven breakdown using L-Carnosine, DermalRx LuShield, dGlyage, and Derm SRC PF. Also includes Edelweiss-ECO, Plantago AO, Sodium Hyaluronate, and Panthenol. 0.5 oz / 15 mL. Pairs with Glyco-Guard for optimal results.

What is glycation and why does it age skin?

Glycation is a process where sugar molecules attach to skin proteins (primarily collagen and elastin), forming Advanced Glycation End-products (A.G.E.s) that cause cross-linking, stiffening, and degradation — leading to loss of firmness, elasticity, and deep wrinkles like smile lines.

What is L-Carnosine?

L-Carnosine (Carnosine + Decarboxy Carnosine HCL) is a naturally occurring dipeptide with anti-glycation and transglycation activity — both preventing new glycation cross-links from forming and helping reverse already-formed ones that have damaged collagen and elastin.

What is dGlyage?

dGlyage (Tripeptide-9 Citrulline) reduces DNA damage from Fenton reaction products and inhibits metal-mediated A.G.E. formation — addressing the heavy-metal-catalyzed glycation pathway that is a distinct and significant driver of structural skin protein degradation.

What is Derm SRC PF?

Derm SRC PF is a triple complex of Bamboo Silica (Bambusa Vulgaris), Pea Extract (Pisum Sativum), and Glucosamine HCL that increases the synthesis of collagen, elastin, and hyaluronic acid — actively rebuilding the structural proteins that glycation has broken down.

How do I use Counter A.G.E. Balancing Serum?

Apply several drops to clean skin morning and evening. Massage gently into face and neck until absorbed. Follow with moisturizer and SPF in the morning. For best results, pair with Circadia Glyco-Guard both morning and night.

Is Auréa Beauty an authorized Circadia retailer?

Yes. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer. All products are 100% authentic and backed by the brand's quality guarantee.

Ideal For

Who Is This For?

All Skin Types Aging Skin Premature Aging Loss of Firmness Smile-Line Wrinkles Collagen Preservation Anti-Glycation Regimen Daily Anti-Aging Serum

For external use only. Avoid contact with eyes. If irritation occurs, discontinue use and consult a healthcare professional. Keep out of reach of children. For optimal anti-glycation results, pair with Circadia Glyco-Guard morning and night as directed by your skincare professional. Sold exclusively through authorized Circadia retailers. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer.

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Shipping & Returns

We ship within the US only.

1. Economy Shipping costs $11.99 and takes 5–8 business days.

2. Express Shipping costs $24.99 and takes 2–3 business days.

Yes, we accept returns within 30 days. Terms and conditions apply, see them here.

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Products & Quality

Auréa Beauty is a proudly woman-owned online store offering premium, medical-grade skincare and advanced beauty devices.

All products are guaranteed authentic, dermatologist-recommended, sourced directly from trusted brands like Bio-Therapeutic, Circadia, GlyMed Plus, and TiZO.