What does Azelaic Acid do in this serum?

Azelaic Acid 0.3% has been shown to reduce the appearance of skin discoloration and redness, acne, and other skin blemishes. It is especially effective for rosacea-prone and acne-prone skin types.

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Circadia Serum 71

Name: Circadia Serum 71 Renewal Serum
Brand: Circadia
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Circadia Serum 71

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Circadia · Renewal Serum · PM Use · 0.5 oz

Serum 71 Renewal Serum

Tranexamic + Mandelic + Azelaic Acids + NeoDermyl® — brightening, calming, and firming in one advanced evening treatment.

A high-performance brightening and strengthening serum that improves tone, reduces redness, and boosts collagen and elastin synthesis for firmer skin. 0.5 oz / 15 mL.

Tranexamic Acid 2%Mandelic Acid 5%Azelaic Acid 0.3%NeoDermyl®CM-Glucan FortePM Use Only

3Active Acids

PMEvening Use

5Key Actives

15mL0.5 oz Retail

Brightening & Renewal Serum

One Evening Serum That Brightens,
Clears, Calms, and Firms.

Serum 71 is Circadia's immune-boosting, nutrient-rich evening serum built around a powerful trio of brightening and resurfacing acids — plus next-generation cellular repair. Tranexamic Acid (2%) treats hyperpigmentation without the irritation or cytotoxicity of hydroquinone — it inhibits tyrosinase activity to visibly lighten and brighten, fades dark spots, and strengthens the skin's barrier function. Mandelic Acid (5%) is a gentle AHA with tyrosinase inhibiting properties that refines texture and supports even tone without causing irritation, making it particularly effective and well-tolerated for a range of skin tones. Azelaic Acid (0.3%) has been shown to reduce the appearance of skin discoloration and redness, acne, and blemishes — especially beneficial for rosacea-prone and reactive skin. CM-Glucan Forte (Magnesium Carboxymethyl Beta-Glucan) is a second-generation stabilized beta-glucan that boosts the skin's immune function, enhances its natural healing ability, soothes irritation, and strengthens the barrier. NeoDermyl® (Copper Lysinate/Prolinate) is the next-generation copper peptide — the "needle-free filler" — that accelerates wound healing and cell regeneration while stimulating collagen and elastin synthesis to improve skin density, firmness, and overall elasticity. This is one serum that addresses hyperpigmentation, adult acne, redness, texture, and visible aging — all in a single evening step.

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Tranexamic Acid 2%

Fades dark spots — tyrosinase inhibitor without irritation

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Mandelic Acid 5%

AHA — refines texture & evens tone gently

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Azelaic Acid 0.3%

Reduces redness, acne & discoloration

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NeoDermyl®

Copper peptide — collagen, elastin, firmness

Key Actives

The Science Behind Serum 71

Brightener 2%

Tranexamic Acid

Treats hyperpigmentation like hydroquinone but without the irritation or cytotoxicity. Inhibits tyrosinase activity to lighten and brighten. Fades dark spots and strengthens the skin's barrier function.

AHA 5%

Mandelic Acid

Alpha-hydroxy acid with tyrosinase inhibiting properties. Gently exfoliates, refines texture, and supports even tone without irritation. Larger molecular size than glycolic acid — well-tolerated by sensitive and darker skin tones.

Clarifying 0.3%

Azelaic Acid

Reduces the appearance of skin discoloration and redness, acne, and blemishes. Particularly effective for rosacea-prone, reactive, and acne-prone skin types.

Immune Support

CM-Glucan Forte

Magnesium Carboxymethyl Beta-Glucan — second-generation stabilized beta-glucan. Boosts the skin's immune function, enhances natural healing ability, soothes irritation, and strengthens the skin barrier.

Copper Peptide

NeoDermyl®

Copper Lysinate/Prolinate — the "needle-free filler." Next-generation copper peptide that accelerates wound healing and cell regeneration while stimulating collagen and elastin synthesis. Improves skin density, firmness, and elasticity.

Humectant

Sodium PCA & Glycerin

Sodium PCA is a natural moisturizing factor (NMF) found in the skin that attracts and retains moisture. Combined with Glycerin, they maintain skin hydration and comfort throughout the active evening treatment.

Benefits

What It Does

Brightening

Tranexamic Acid and Mandelic Acid inhibit tyrosinase to fade dark spots, even tone, and brighten hyperpigmentation.

Calming

Azelaic Acid and CM-Glucan Forte reduce redness, calm acne, and soothe reactive and sensitive skin overnight.

Firming

NeoDermyl® copper peptide boosts collagen and elastin synthesis for visibly improved density, firmness, and elasticity.

Directions

How to Apply

Evening use only. Follow with moisturizer.

1

Cleanse

In the evening, cleanse skin thoroughly and pat dry. Serum 71 is designed for the evening routine to work overnight while the skin undergoes its natural repair cycle.

2

Apply Serum

Apply several drops to fingertips and smooth over the face and neck. Avoid contact with eyes. Allow to absorb before the next step.

3

Follow with Moisturizer

Follow with a moisturizer or corrective lotion to seal in the serum and support barrier recovery overnight.

4

Morning: Always Apply SPF

Always follow with a broad-spectrum SPF the next morning. Active acid use increases photosensitivity — daily sun protection is essential.

Formulation

Ingredients

Key Actives

Tranexamic Acid (2%) — inhibits tyrosinase activity; treats hyperpigmentation; fades dark spots; strengthens barrier function; no irritation or cytotoxicity.
Mandelic Acid (5%) — AHA with tyrosinase inhibiting properties; gently exfoliates; refines texture; supports even tone; suitable for sensitive and darker skin tones.
Azelaic Acid (0.3%) — reduces redness, acne, discoloration, and blemishes; beneficial for rosacea-prone and reactive skin.
CM-Glucan Forte (Magnesium Carboxymethyl Beta-Glucan) — second-generation beta-glucan; boosts skin immune function; enhances healing; soothes irritation; strengthens barrier.
NeoDermyl® (Copper Lysinate/Prolinate) — next-generation copper peptide; "needle-free filler"; stimulates collagen and elastin; improves density, firmness, and elasticity.
Sodium PCA — natural moisturizing factor; attracts and retains moisture.

Full Ingredient List

Aqua/Water, Propanediol, Mandelic Acid, Butylene Glycol, Tranexamic Acid, Phenoxyethanol, Sodium PCA, Hydroxyethylcellulose, Sodium Hydroxide, Azelaic Acid, Glycerin, Magnesium Carboxymethyl Beta-Glucan, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Alcohol, Sodium Hydroxide.

Specifications

Product Details

Brand	Circadia by Dr. Pugliese
Size	0.5 oz / 15 mL
Product Type	Brightening & Renewal Evening Serum
Active Acids	Tranexamic Acid 2% · Mandelic Acid 5% · Azelaic Acid 0.3%
Use	Evening only — after cleansing; follow with moisturizer
Application	Several drops smoothed over face and neck; avoid eye area
Skin Types	Hyperpigmented · Red/Sensitive · Acne-Prone · Aging/Dull
Key Technology	NeoDermyl® Copper Peptide · CM-Glucan Forte

FAQ

Common Questions

Everything you need to know about Serum 71 Renewal Serum.

What is Circadia Serum 71 Renewal Serum?

An immune-boosting, high-performance evening serum with Tranexamic Acid 2%, Mandelic Acid 5%, and Azelaic Acid 0.3% for hyperpigmentation, redness, and texture. CM-Glucan Forte supports healing and NeoDermyl® copper peptide boosts collagen and elastin for firmer skin.

What does Tranexamic Acid do in Serum 71?

Tranexamic Acid 2% treats hyperpigmentation like hydroquinone but without irritation or cytotoxicity. It inhibits tyrosinase activity to lighten and brighten the skin, fades dark spots, and strengthens the skin's barrier function.

What is NeoDermyl® and what does it do?

NeoDermyl® (Copper Lysinate/Prolinate) is a next-generation copper peptide known as the "needle-free filler." It accelerates wound healing and cell regeneration while stimulating collagen and elastin synthesis, improving skin density, firmness, and overall elasticity.

What is CM-Glucan Forte?

CM-Glucan Forte (Magnesium Carboxymethyl Beta-Glucan) is a second-generation stabilized beta-glucan that rebalances the skin's immune system, enhances its natural healing ability, soothes irritation, and strengthens the skin barrier.

Is Serum 71 suitable for sensitive skin?

Yes — Mandelic Acid is one of the gentlest AHAs available and Azelaic Acid actively calms redness. CM-Glucan Forte further soothes the skin's immune response, making this suitable for sensitive, reactive, and rosacea-prone skin.

How do I use Circadia Serum 71?

Apply several drops to fingertips and smooth over the face and neck in the evening after cleansing. Avoid contact with eyes. Follow with a moisturizer or corrective lotion. Always apply a broad-spectrum SPF the following morning.

Can Serum 71 be used for melasma?

Yes — the 2% Tranexamic Acid interrupts pigment signaling pathways responsible for melasma and stubborn dark patches, making it an effective non-hydroquinone option for melasma treatment when used consistently.

Ideal For

Who Is This For?

Hyperpigmented SkinMelasmaPost-Acne Dark SpotsRedness / RosaceaAcne-ProneAging SkinDull SkinSensitive Skin

For external use only. Evening use only. Apply to face and neck and avoid contact with eyes. If irritation occurs, discontinue use. Keep out of reach of children. Always follow with a broad-spectrum SPF the following morning — active acid use increases photosensitivity. Circadia products are developed for professional skincare use. Sold exclusively through authorized Circadia retailers. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer.

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Shipping & Returns

We ship within the US only.

1. Economy Shipping costs $11.99 and takes 5–8 business days.

2. Express Shipping costs $24.99 and takes 2–3 business days.

Yes, we accept returns within 30 days. Terms and conditions apply, see them here.

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Products & Quality

Auréa Beauty is a proudly woman-owned online store offering premium, medical-grade skincare and advanced beauty devices.

All products are guaranteed authentic, dermatologist-recommended, sourced directly from trusted brands like Bio-Therapeutic, Circadia, GlyMed Plus, and TiZO.