What is the Apple Stem Cell Extract in MeriStem?

Malus Domestica Fruit Cell Culture Extract is derived from the stem cells of a rare longevity Swiss apple. It increases the vitality of skin stem cells, delays cellular senescence (aging), combats chronological aging, and helps skin stem cells maintain their characteristics and capacity to build new tissue.

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Circadia MeriStem Antioxidant Serum

Name: Circadia MeriStem Antioxidant Serum
Brand: Circadia
Availability: InStock

$45.00

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Circadia MeriStem Antioxidant Serum

$45.00

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Circadia · Plant Stem Cell Serum · Authorized Retailer · 0.5 oz

MeriStem
Antioxidant Serum

Apple Stem Cell + Edelweiss Meristem + Cyclopeptide-5 — revitalizes, firms, and protects with plant stem cell technology.

An advanced rejuvenating serum that harnesses the longevity science of plant stem cell technology — revitalizing skin vitality, improving firmness and elasticity, and delivering powerful antioxidant protection for more youthful-looking skin. 0.5 oz / 15 mL.

Apple Stem CellEdelweiss MeristemCyclopeptide-5Aloe Vera Gel-EcoEctoin0.5 oz / 15 mL

AM/PMDaily Use

15%Wrinkle Depth Reduction*

AllSkin Types

StemCell Technology

Plant Stem Cell Rejuvenating Serum

Revitalizes Skin Vitality, Firms, and Protects
with Alpine and Swiss Apple Stem Cell Technology.

Circadia MeriStem Antioxidant Serum is a professional-grade rejuvenating treatment built on the science of plant meristem cell culture technology. Apple Stem Cell Extract (Malus Domestica Fruit Cell Culture Extract) is a liposomal preparation from the stem cells of a rare longevity Swiss apple — increasing skin stem cell vitality, delaying cellular senescence, combating chronological aging, and helping skin stem cells maintain their capacity to build new tissue. Edelweiss Meristem Cell Extract (Leontopodium Alpinum Meristem Cell Culture) is derived from the stem cells of the hardy alpine Edelweiss plant. It provides antioxidant, anti-hyaluronidase, and anti-collagenase activity — protecting hyaluronic acid and collagen from enzymatic breakdown — and clinical data demonstrates a 15% reduction in wrinkle depth around the eye after only 20 days of treatment. Cyclopeptide-5 (Cyclotetrapeptide-24 Aminocyclohexane Carboxylate) is a novel cyclopeptide that binds integrins and increases signaling for extracellular matrix production and cell-to-cell crosstalk — improving tensile strength, compressive strength, elasticity, firmness, and wrinkle depth. Aloe Vera Gel-Eco (Aloe Barbadensis) contains acemannan and mucilaginous polysaccharides that stimulate fibroblast growth, angiogenesis, and re-epithelialization while reducing inflammation and increasing collagen synthesis. Ectoin provides additional environmental stress protection.

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Apple Stem Cell

Swiss longevity apple — delays senescence

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Edelweiss Meristem

Anti-collagenase — 15% wrinkle depth reduction*

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Cyclopeptide-5

Integrin binding — ECM production & firmness

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Authorized Retailer

100% authentic Circadia — guaranteed

Key Actives

The Plant Stem Cell Science Behind Younger Skin

Longevity Stem Cell

Apple Stem Cell Extract

Malus Domestica Fruit Cell Culture Extract — liposomal preparation from the stem cells of a rare longevity Swiss apple. Increases skin stem cell vitality, delays cellular senescence, and helps skin maintain its capacity to build new tissue.

Alpine Stem Cell

Edelweiss Meristem Extract

Leontopodium Alpinum Meristem Cell Culture — provides antioxidant, anti-hyaluronidase, and anti-collagenase activity. Clinically shown to reduce wrinkle depth by 15% around the eye after 20 days of treatment by protecting HA and collagen from enzymatic breakdown.

Integrin-Binding Peptide

Cyclopeptide-5

Cyclotetrapeptide-24 Aminocyclohexane Carboxylate — a novel cyclopeptide that binds integrins and increases cell-to-cell signaling for extracellular matrix production. Improves tensile and compressive strength, elasticity, firmness, and reduces wrinkle depth.

Healing Botanical

Aloe Vera Gel-Eco

Aloe Barbadensis Leaf Juice — rich in acemannan and mucilaginous polysaccharides. Stimulates fibroblast growth, angiogenesis, and re-epithelialization. Reduces inflammation and increases collagen synthesis while providing deep soothing and hydration.

Stress Shield

Ectoin

A natural extremolyte produced by bacteria living in extreme environments. Provides a protective molecular shield around skin cells and biomolecules, defending against environmental stressors including UV, temperature extremes, and pollution.

Collagen Co-Factor

Lecithin

Phosphatidylcholine-rich lecithin provides delivery vehicle benefits for the stem cell actives while also restoring moisture to the skin's surface and supporting barrier lipid renewal alongside the formula's active ingredients.

Benefits

What It Does

Vitality & Longevity

Apple Stem Cell Extract delays cellular senescence and helps skin stem cells maintain their tissue-building capacity — supporting long-term skin vitality from within.

Firmness & Wrinkle Depth

Edelweiss Meristem protects collagen and HA from enzymatic breakdown. Cyclopeptide-5 boosts ECM production and integrin signaling — improving firmness, elasticity, and visibly reducing wrinkle depth.

Antioxidant Protection

Edelweiss Meristem, Aloe Vera, and Ectoin combine to defend the complexion against oxidative stress and environmental damage that accelerates visible signs of aging.

Directions

How to Use

Morning and evening after cleansing.

1

Cleanse

Cleanse thoroughly morning and evening. MeriStem Serum is applied directly to clean skin before moisturizer for optimal stem cell active absorption.

2

Apply

Apply several drops to fingertips and smooth over face and neck. Avoid contact with eyes. Follow with your moisturizer. In the morning, follow with broad-spectrum SPF.

Formulation

Ingredients

Key Actives

Apple Stem Cell Extract (Malus Domestica Fruit Cell Culture Extract) — liposomal; increases skin vitality; delays senescence; preserves stem cell characteristics.

Edelweiss Meristem Cell Extract (Leontopodium Alpinum Meristem Cell Culture) — antioxidant; anti-hyaluronidase; anti-collagenase; 15% wrinkle depth reduction in 20 days (clinical data).

Cyclopeptide-5 (Cyclotetrapeptide-24 Aminocyclohexane Carboxylate) — integrin-binding; increases ECM production; improves tensile strength, elasticity, firmness, and wrinkle depth.

Aloe Vera Gel-Eco (Aloe Barbadensis Leaf Juice) — acemannan and mucilaginous polysaccharides; wound healing; fibroblast stimulation; collagen synthesis; anti-inflammatory.

Ectoin — extremolyte; molecular shield; protects cells from environmental stressors.

Full Ingredient List

Aqua/Water, Citric Acid, Pentylene Glycol, Aloe Barbadensis Leaf Juice, Xanthan Gum, Ammonium Acryloyldimethyltaurate/VP Copolymer, Caprylyl Glycol, Leontopodium Alpinum Meristem Cell Culture, Alcohol, Phenoxyethanol, Tetrasodium EDTA, Malus Domestica Fruit Cell Culture Extract, Hexylene Glycol, Ectoin, Lecithin, Glycerin, Sodium Hydroxide, Sodium Metabisulfite, Sodium Benzoate, Potassium Sorbate, Cyclotetrapeptide-24 Aminocyclohexane Carboxylate.

Specifications

Product Details

Brand	Circadia by Dr. Pugliese
Size	0.5 oz / 15 mL retail
Product Type	Plant stem cell rejuvenating antioxidant serum
Skin Types	All Skin Types · Aging · Loss of Firmness · Dull or Tired Skin
Application	Morning and evening after cleansing; apply several drops; smooth over face and neck; avoid eye contact; follow with moisturizer and SPF (AM)
Key Actives	Apple Stem Cell (Malus Domestica), Edelweiss Meristem (Leontopodium Alpinum), Cyclopeptide-5 (Cyclotetrapeptide-24), Aloe Vera Gel-Eco, Ectoin
Sold By	Auréa Beauty — Authorized Circadia Retailer (myaurea.beauty)

*Based on ingredient supplier clinical data for Leontopodium Alpinum Meristem Cell Culture (Edelweiss stem cell extract). Individual results may vary.

FAQ

Common Questions

Everything you need to know about Circadia MeriStem Antioxidant Serum.

What is Circadia MeriStem Antioxidant Serum?

An advanced rejuvenating serum using plant stem cell technology. Formulated with Apple Stem Cell Extract, Edelweiss Meristem Cell Extract, Cyclopeptide-5, Aloe Vera Gel-Eco, and Ectoin. Revitalizes skin, improves firmness and elasticity, and provides antioxidant protection. 0.5 oz / 15 mL.

What is the Apple Stem Cell Extract?

Malus Domestica Fruit Cell Culture Extract — a liposomal preparation from the stem cells of a rare Swiss apple known for its longevity. It increases the vitality of skin stem cells, delays senescence, and helps skin maintain its capacity to build new tissue.

What is Edelweiss Meristem Cell Extract?

Leontopodium Alpinum Meristem Cell Culture Extract from the hardy alpine Edelweiss plant. It provides antioxidant, anti-hyaluronidase, and anti-collagenase activity — protecting HA and collagen from enzymatic breakdown — with clinical data showing 15% wrinkle depth reduction around the eye after 20 days of treatment.

What is Cyclopeptide-5?

Cyclopeptide-5 (Cyclotetrapeptide-24 Aminocyclohexane Carboxylate) is a novel cyclopeptide that binds integrins to increase signaling for extracellular matrix production and cell crosstalk — improving tensile strength, elasticity, firmness, and wrinkle depth.

How do I use Circadia MeriStem Serum?

Morning and evening after cleansing, apply several drops to fingertips and smooth over face and neck. Avoid eye contact. Follow with moisturizer and SPF in the morning.

Is Auréa Beauty an authorized Circadia retailer?

Yes. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer. All products are 100% authentic and backed by the brand's quality guarantee.

Ideal For

Who Is This For?

All Skin TypesAging SkinLoss of FirmnessDull or Tired SkinWrinkle ReductionAntioxidant SupportStem Cell Anti-AgingDaily Repair Serum

For external use only. Avoid contact with eyes. If irritation occurs, discontinue use. Keep out of reach of children. *15% wrinkle depth reduction figure is based on ingredient supplier clinical data; individual results may vary. Sold exclusively through authorized Circadia retailers. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer.

Payment Protection + Pay Later Options
Easy 30-Day Returns

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Luxury That Loves Your Skin, Your Hair, and the Planet

Auréa Beauty stands for more than visible results—we stand for responsibility. We believe in derm-developed, cruelty-free, and sustainably sourced formulas.

✔ We're proudly woman-owned: created with heart, honesty, and intention.

✔ Real, medical-grade skincare and haircare you can actually trust—without fluff and false promises.

✔ We make self-care simple, personal, and powerful.

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Questions? We've got you!

Shipping & Returns

We ship within the US only.

1. Economy Shipping costs $11.99 and takes 5–8 business days.

2. Express Shipping costs $24.99 and takes 2–3 business days.

Yes, we accept returns within 30 days. Terms and conditions apply, see them here.

We accept a variety of payment methods including major credit cards (Visa, Mastercard, etc.), plus alternative payment options like Apple Pay, Shop Pay, and PayPal.

Once your order is placed and shipped, you will receive a confirmation email. Use the tracking information provided to follow delivery.

If you're missing tracking or have any concerns, please reach out to our customer support.

Products & Quality

Auréa Beauty is a proudly woman-owned online store offering premium, medical-grade skincare and advanced beauty devices.

All products are guaranteed authentic, dermatologist-recommended, sourced directly from trusted brands like Bio-Therapeutic, Circadia, GlyMed Plus, and TiZO.